Isolated Adrenocorticotropic Hormone Deficiency in Melanoma Patients Treated with Nivolumab
نویسندگان
چکیده
منابع مشابه
Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma
We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently simultaneous isolated adrenocorticotropic hormone (ACTH) deficiency and severe hypercalcemia. Although isolated ACTH deficiency and hypercalcemia due to nivolumab therapy are both rare occurrences, these conditions can ofte...
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Nivolumab has promising efficacy for treating various advanced malignant tumors, although it has been reported to induce a wide range of autoimmune adverse effects. We herein report the case of a patient with metastatic lung adenocarcinoma who developed adrenal insufficiency after 12 cycles of nivolumab treatment. Endocrine test results supported a diagnosis of isolated adrenocorticotropic horm...
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We found symptomatic hyponatremia in four elderly patients in which serum sodium (Na) levels ranged from 101 to 122 mEq/l. All 4 patients had low levels of plasma adrenocorticotropic hormone (ACTH), serum cortisol, and urinary excretion of 17-OHCS, and poor responses of ACTH to exogenous insulin and antidiuretic hormone (ADH). Other pituitary hormones were all normal. They were therefore diagno...
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A 22-year-old man was hospitalized with nausea. His serum sodium, adrenocorticotropic hormone (ACTH), and cortisol levels were 108 mmol/L (range, 138-145), 2.2 pg/mL (range, 7.2-63.3), and 0.08 μg/dL (range, 4.64-24.56), respectively. The levels of other anterior pituitary hormones were as follows: growth hormone 2.46 ng/mL (range, 0.663.68), thyroid-stimulating hormone 0.625 μIU/mL (range, 0.5...
متن کاملIsolated Adrenocorticotropic Hormone (acth) Deficiency Associated with Hashimoto's Disease
Isolated ACTH deficiency (IAD) is a rare disease which is characterized by secondary adrenal insufficiency with low cortisol production and normal secretion of pituitary hormones other than ACTH. Isolated ACTH deficiency has rare association with Hashimoto’s disease which is characterized by autoimmune origin. This suggests the possibility of common autoimmune process affecting both the pituita...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2018
ISSN: 0001-5555
DOI: 10.2340/00015555-2902